3-[(4-chloroanilino)sulfonyl]thiophene-2-carboxylic acid

**3-[(4-Chloroanilino)sulfonyl]thiophene-2-carboxylic acid (STC)** is a small molecule organic compound classified as a sulfanilide. It features a thiophene ring substituted with a carboxylic acid group and a sulfamoyl group derived from 4-chlorophenyl, which contributes to its unique chemical properties and potential biological activities[7]. The compound has been investigated as an inhibitor of AmpC beta-lactamase, an enzyme that confers resistance to beta-lactam antibiotics in bacteria. Specifically, it acts as a non-beta-lactam inhibitor of class C beta-lactamase AmpC (Ki = 26 μM), providing insights into overcoming antibiotic resistance mechanisms[8]. While specific pharmacological data are limited, compounds in the sulfanilide class often exhibit antimicrobial properties by interfering with folic acid synthesis; however, direct evidence for this mechanism in STC is not established[7].

Other names

3-((4-chloroanilino)sulfonyl)thiophene-2-carboxylic acid3-[(4-chlorophenyl)sulfamoyl]thiophene-2-carboxylic acid496051-23-1YPG9JNK4RXYPG-9JNK4RXYPG 9JNK4RXDTXSID20332234DTXSID-20332234DTXSID 20332234